The objective of the present study was to develop the extended release film coated tablets of Divalproex sodium to mask the foul taste of divalproex sodium, improve the product stability and to modulate the release properties. In the present study extended release tablet of Divalproex sodium was prepared by using wet granulation method. Different formulations were made by using two release rate controlling polymer like HPMC K100M CR and HPMC K15M CR and finally tablets were made film coated by using specific coating polymer. All the Prepared formulations were evaluated for the physical characteristics, in vitro dissolution and stability at 40�°C/ 75% RH for three months. The release of Divalproex sodium from the film coated tablet for a period up to 18 hrs was recorded in controlled manner. The model for analysis of formulation DF5 fitted showed that the release of Divalproex sodium follows zero order kinetics (R2= 0.987) which suggested that the drug release was constant with time up to 18 hrs.
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